Transethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A

Hansong Wang; Terrilea Burnett; Suminori Kono; Christopher Haiman; Motoki Iwasaki; Lynne Wilkens; Lenora Loo; David Van Den Berg; Laurence Kolonel; Brian Henderson; Temitope Keku; Robert Sandler; Lisa Signorello; William Blot; Polly Newcomb; Mala Pande; Christopher Amos; Dee West; Stephane Bezieau; Sonja Berndt; Brent Zanke; Li Hsu; Noralane Lindor; Robert Haile; John Hopper; Mark Jenkins; Steven Gallinger; Graham Casey; Stephanie Stenzel; Fredrick Schumacher; Ulrike Peters; Stephen Gruber; Shoichiro Tsugane; Dan Stram; Loic L Marchand

Conference Proceedings

Transethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A

Hansong Wang, Terrilea Burnett, Suminori Kono, Christopher Haiman, Motoki Iwasaki, Lynne Wilkens, Lenora Loo, David Van Den Berg, Laurence Kolonel, Brian Henderson, Temitope Keku, Robert Sandler, Lisa Signorello, William Blot, Polly Newcomb, Mala Pande, Christopher Amos, Dee West, Stephane Bezieau, Sonja Berndt Show all

CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2014

DOI: 10.1158/1538-7445.AM2014-LB-282

Abstract

Abstract To identify genetic variants that contribute to colorectal cancer (CRC) susceptibility, we performed a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, followed by a replication of genome-wide statistically significant associations (P < 5E-8) in 16,823 cases and 18,211 controls of European ancestry. This study revealed a new pan-ethnic CRC risk locus at 10q25 (rs12241008, intronic to VTI1A; P=1.5E-9), providing additional insight into the etiology of CRC and highlighting the value of association mapping in diverse populations. Citation F..

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